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Literature summary for 3.1.2.6 extracted from

  • Mannervik, B.
    Molecular enzymology of the glyoxalase system (2008), Drug Metabol. Drug Interact., 23, 13-27.
    View publication on PubMed

Application

Application Comment Organism
drug development cancer therapy, inhibitors of the glyoxalase system would be expected to suppress the growth of cancer cells and could find clinical use as anticancer drug Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
transcription factor p63 upregulation of glyoxalase II Mus musculus
transcription factor p73 upregulation of glyoxalase II Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
mitochondrion
-
Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ catalytic process of glyoxalase II involves a water moleule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron Mus musculus
Zn2+ essential role in catalytic mechanism Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron ?
-
?
additional information Mus musculus glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids ?
-
?
S-(2-hydroxyacyl)glutathione + H2O Mus musculus second step in the glyoxalase system glutathione + a 2-hydroxycarboxylate anion regeneration of glutathione for the first step in the glyoxalase system ir
S-D-lactoylglutathione + H2O Mus musculus
-
D-lactate + glutathione
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by affinity chromatography Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron Mus musculus ?
-
?
additional information glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids Mus musculus ?
-
?
S-(2-hydroxyacyl)glutathione + H2O second step in the glyoxalase system Mus musculus glutathione + a 2-hydroxycarboxylate anion regeneration of glutathione for the first step in the glyoxalase system ir
S-D-lactoylglutathione + H2O
-
Mus musculus D-lactate + glutathione
-
?

Subunits

Subunits Comment Organism
monomer mammalian glyoxalase II Mus musculus

Synonyms

Synonyms Comment Organism
glyoxalase II
-
Mus musculus