Application | Comment | Organism |
---|---|---|
drug development | cancer therapy, inhibitors of the glyoxalase system would be expected to suppress the growth of cancer cells and could find clinical use as anticancer drug | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
transcription factor p63 | upregulation of glyoxalase II | Mus musculus | |
transcription factor p73 | upregulation of glyoxalase II | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | catalytic process of glyoxalase II involves a water moleule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron | Mus musculus | |
Zn2+ | essential role in catalytic mechanism | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron | ? | - |
? | |
additional information | Mus musculus | glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids | ? | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | Mus musculus | second step in the glyoxalase system | glutathione + a 2-hydroxycarboxylate anion | regeneration of glutathione for the first step in the glyoxalase system | ir | |
S-D-lactoylglutathione + H2O | Mus musculus | - |
D-lactate + glutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by affinity chromatography | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalytic process involves a water molecule activated by a binuclear metal center containing one zinc atom plus a second bivalent metal ion which could be a zinc or an iron | Mus musculus | ? | - |
? | |
additional information | glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids | Mus musculus | ? | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | second step in the glyoxalase system | Mus musculus | glutathione + a 2-hydroxycarboxylate anion | regeneration of glutathione for the first step in the glyoxalase system | ir | |
S-D-lactoylglutathione + H2O | - |
Mus musculus | D-lactate + glutathione | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | mammalian glyoxalase II | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
glyoxalase II | - |
Mus musculus |