Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cardiolipin | negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction | Homo sapiens | |
dioleoyl phosphatidic acid | i.e. DOPA, negatively charged phospholipid, strongly inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction | Homo sapiens | |
dipalmitoylphosphatidylserine | negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction | Homo sapiens | |
additional information | negatively charged phospholipids, like dioleoyl phosphatidic acid, cardiolipin, and phosphatidylserine, specifically interact with the enzyme, but do not inhibit the mitochondrial isozyme, no effect by neutral phospholipids | Bos taurus | |
additional information | no effect by neutral phospholipids, phospholipid binding studies | Homo sapiens | |
phosphatidylserine | negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics in presence of liposomes consisting of different phospholipids | Homo sapiens | |
additional information | - |
additional information | kinetics in presence of liposomes consisting of different phospholipids | Bos taurus | |
0.152 | - |
S-(2-hydroxyacyl)glutathione | cytosolic isozyme, pH 7.2, 25°C, in presence of dioleoyl phosphatidic acid | Homo sapiens | |
0.152 | - |
S-(2-hydroxyacyl)glutathione | mitochondrial isozyme, pH 7.2, 25°C | Bos taurus | |
0.162 | - |
S-(2-hydroxyacyl)glutathione | mitochondrial isozyme, pH 7.2, 25°C, in presence of dioleoyl phosphatidic acid | Bos taurus | |
0.169 | - |
S-(2-hydroxyacyl)glutathione | cytosolic isozyme, pH 7.2, 25°C, in presence of cardiolipin | Homo sapiens | |
0.191 | - |
S-(2-hydroxyacyl)glutathione | cytosolic isozyme, pH 7.2, 25°C, in presence of dipalmitoylphosphatidylserine | Homo sapiens | |
0.191 | - |
S-(2-hydroxyacyl)glutathione | mitochondrial isozyme, pH 7.2, 25°C, in presence of cardiolipin | Bos taurus | |
0.201 | - |
S-(2-hydroxyacyl)glutathione | cytosolic isozyme, pH 7.2, 25°C | Homo sapiens | |
0.255 | - |
S-(2-hydroxyacyl)glutathione | mitochondrial isozyme, pH 7.2, 25°C, in presence of phosphatidylserine | Bos taurus | |
0.283 | - |
S-(2-hydroxyacyl)glutathione | mitochondrial isozyme, pH 7.2, 25°C, in presence of dipalmitoylphosphatidylserine | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic isozyme | Homo sapiens | 5829 | - |
mitochondrion | mitochondrial isozyme | Bos taurus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-(2-hydroxyacyl)glutathione + H2O | Homo sapiens | enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal | glutathione + a 2-hydroxycarboxylate anion | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | Bos taurus | enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal | glutathione + a 2-hydroxycarboxylate anion | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
mitochondrial isozyme | - |
Homo sapiens | - |
recombinant cytosolic isozyme expressed in Escherichia coli | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-(2-hydroxyacyl)glutathione + H2O | - |
Homo sapiens | glutathione + a 2-hydroxycarboxylate anion | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | - |
Bos taurus | glutathione + a 2-hydroxycarboxylate anion | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal | Homo sapiens | glutathione + a 2-hydroxycarboxylate anion | - |
? | |
S-(2-hydroxyacyl)glutathione + H2O | enzyme is part of the glyoxalase system and involved in detoxification of methylglyoxal | Bos taurus | glutathione + a 2-hydroxycarboxylate anion | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetoacetylglutathione hydrolase | - |
Homo sapiens |
acetoacetylglutathione hydrolase | - |
Bos taurus |
Germ cell specific protein | - |
Homo sapiens |
Germ cell specific protein | - |
Bos taurus |
GLO II | - |
Homo sapiens |
GLO II | - |
Bos taurus |
glyoxalase II | - |
Homo sapiens |
glyoxalase II | - |
Bos taurus |
hydrolase, acetoacetylglutathione | - |
Homo sapiens |
hydrolase, acetoacetylglutathione | - |
Bos taurus |
hydrolase, hydroxyacylglutathione | - |
Homo sapiens |
hydrolase, hydroxyacylglutathione | - |
Bos taurus |
Round spermatid protein RSP29 | - |
Homo sapiens |
Round spermatid protein RSP29 | - |
Bos taurus |
S-2-hydroxylacylglutathione hydrolase | - |
Homo sapiens |
S-2-hydroxylacylglutathione hydrolase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
7.2 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
dioleoyl phosphatidic acid | cytosolic isozyme, pH 7.2, 25°C | Homo sapiens | |
0.0022 | - |
dipalmitoylphosphatidylserine | cytosolic isozyme, pH 7.2, 25°C | Homo sapiens | |
0.006 | - |
cardiolipin | cytosolic isozyme, pH 7.2, 25°C | Homo sapiens | |
0.055 | - |
phosphatidylserine | cytosolic isozyme, pH 7.2, 25°C | Homo sapiens |