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Literature summary for 3.1.2.6 extracted from

  • Yang, K.W.; Sobieski, D.N.; Carenbauer, A.L.; Crawford, P.A.; Makaroff, C.A.; Crowder, M.W.
    Explaining the inhibition of glyoxalase II by 9-fluorenylmethoxycarbonyl-protected glutathione derivatives (2003), Arch. Biochem. Biophys., 414, 271-278.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K65A site-directed mutagenesis, reduced sensitivity to 9-fluoromethoxycarbonyl- or phenylmethoxycarbonyl-protected glutathione derivative inhibitors Arabidopsis thaliana
L9A site-directed mutagenesis, reduced sensitivity to 9-fluoromethoxycarbonyl- or phenylmethoxycarbonyl-protected glutathione derivative inhibitors Arabidopsis thaliana
W57D site-directed mutagenesis, reduced sensitivity to 9-fluoromethoxycarbonyl- or phenylmethoxycarbonyl-protected glutathione derivative inhibitors Arabidopsis thaliana
W57N site-directed mutagenesis, reduced sensitivity to 9-fluoromethoxycarbonyl- or phenylmethoxycarbonyl-protected glutathione derivative inhibitors Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione
-
Arabidopsis thaliana
N,S-bis-(phenylmethoxycarbonyl)glutathione
-
Arabidopsis thaliana
N-(9-fluorenylmethoxycarbonyl)-S-phenylmethoxycarbonylglutathione
-
Arabidopsis thaliana
N-(9-fluorenylmethoxycarbonyl)glutathione
-
Arabidopsis thaliana
N-phenylmethoxycarbonyl-S-(9-fluorenylmethoxycarbonyl)glutathione
-
Arabidopsis thaliana
N-phenylmethoxycarbonylglutathione
-
Arabidopsis thaliana
S-(9-fluorenylmethoxycarbonyl)glutathione
-
Arabidopsis thaliana
S-(N-hydroxy-N-bromophenylcarbamoyl)glutathione
-
Arabidopsis thaliana
S-phenylmethoxycarbonylglutathione
-
Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.151
-
S-D-lactoylglutathione recombinant mutant L9A, pH 7.2, 25°C Arabidopsis thaliana
0.256
-
S-D-lactoylglutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.268
-
S-D-lactoylglutathione recombinant mutant W57D, pH 7.2, 25°C Arabidopsis thaliana
0.288
-
S-D-lactoylglutathione recombinant mutant K65A, pH 7.2, 25°C Arabidopsis thaliana
0.318
-
S-D-lactoylglutathione recombinant mutant W57N, pH 7.2, 25°C Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O24496
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-D-lactoylglutathione + H2O
-
Arabidopsis thaliana glutathione + D-lactate
-
?

Synonyms

Synonyms Comment Organism
acetoacetylglutathione hydrolase
-
Arabidopsis thaliana
Germ cell specific protein
-
Arabidopsis thaliana
GLO II
-
Arabidopsis thaliana
GLX2-2
-
Arabidopsis thaliana
glyoxalase II
-
Arabidopsis thaliana
hydrolase, acetoacetylglutathione
-
Arabidopsis thaliana
hydrolase, hydroxyacylglutathione
-
Arabidopsis thaliana
Round spermatid protein RSP29
-
Arabidopsis thaliana
S-2-hydroxylacylglutathione hydrolase
-
Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Arabidopsis thaliana

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
322
-
S-D-lactoylglutathione recombinant mutant L9A, pH 7.2, 25°C Arabidopsis thaliana
370
-
S-D-lactoylglutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
386
-
S-D-lactoylglutathione recombinant mutant K65A, pH 7.2, 25°C Arabidopsis thaliana
421
-
S-D-lactoylglutathione recombinant mutant W57N, pH 7.2, 25°C Arabidopsis thaliana
426
-
S-D-lactoylglutathione recombinant mutant W57D, pH 7.2, 25°C Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00089
-
N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.0017
-
N-(9-fluorenylmethoxycarbonyl)-S-phenylmethoxycarbonylglutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.002
-
N-phenylmethoxycarbonyl-S-(9-fluorenylmethoxycarbonyl)glutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.0021
-
N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione recombinant mutant W57D, pH 7.2, 25°C Arabidopsis thaliana
0.0023
-
N,S-bis-(phenylmethoxycarbonyl)glutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.0027
-
N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione recombinant mutants W57N and K65A, pH 7.2, 25°C Arabidopsis thaliana
0.0028
-
N,S-bis-(9-fluorenylmethoxycarbonyl)glutathione recombinant mutant L9A, pH 7.2, 25°C Arabidopsis thaliana
0.0049
-
S-phenylmethoxycarbonylglutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.0056
-
N-phenylmethoxycarbonylglutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.014
-
S-(9-fluorenylmethoxycarbonyl)glutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana
0.015
-
N-(9-fluorenylmethoxycarbonyl)glutathione recombinant wild-type enzyme, pH 7.2, 25°C Arabidopsis thaliana