Any feedback?
Literature summary for 3.1.2.5 extracted from
- beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase of rat liver (1981), Biochim. Biophys. Acta, 666, 181-190.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.27 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | microsomal | Rattus norvegicus |  |
| 0.83 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | soluble enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, crude enzyme, 2 days, 40% loss of activity | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | - |
Rattus norvegicus | CoA + 3-hydroxy-3-methylglutarate | - |
? | |
| (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | - |
Rattus norvegicus | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
microsomal, 6 h stable | Rattus norvegicus |
| 20 | - |
without substrate, microsomal, 31% loss of activity after 15 min | Rattus norvegicus |
| 37 | - |
without substrate, cytoplasm, 25% loss of activity after 30 min, microsomal, 50% loss of activity after 5 min | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
microsomal | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
