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Literature summary for 3.1.2.28 extracted from

  • Widhalm, J.R.; van Oostende, C.; Furt, F.; Basset, G.J.
    A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1 (2009), Proc. Natl. Acad. Sci. USA, 106, 5599-5603.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.2.28

Cloned(Commentary)

Cloned (Comment) Organism
expressed as a recombinant His-fusion protein Synechocystis sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15478
-
 x * 15478, calculated from sequence Synechocystis sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,4-dihydroxy-2-naphthoyl-CoA + H2O Synechocystis sp. the reaction is involved in phylloquinone (vitamin K1) biosynthesis CoA + 1,4-dihydroxy-2-naphthoate
-
 ?

Organism

Organism UniProt Comment Textmining
Synechocystis sp. Q55777 strain PCC 6803
-

Purification (Commentary)

Purification (Comment) Organism
-
 Synechocystis sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-dihydroxy-2-naphthoyl-CoA + H2O the reaction is involved in phylloquinone (vitamin K1) biosynthesis Synechocystis sp. CoA + 1,4-dihydroxy-2-naphthoate
-
 ?
1,4-dihydroxy-2-naphthoyl-CoA + H2O the enzyme is specific for 1,4-dihydroxy-2-naphthoyl-CoA and displays no activity against benzoyl-CoA, phenylacetyl-CoA, succinyl-CoA and palmitoyl-CoA Synechocystis sp. CoA + 1,4-dihydroxy-2-naphthoate
-
 ?

Subunits

Subunits Comment Organism
? x * 15478, calculated from sequence Synechocystis sp.

Synonyms

Synonyms Comment Organism
DHNA-CoA thioesterase
-
 Synechocystis sp.
slr0204
-
 Synechocystis sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Synechocystis sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Synechocystis sp.

General Information

General Information Comment Organism
malfunction knockout mutant accumulates 1,4-dihydroxy-2-naphthoyl-CoA, contains 13fold less phylloquinone than the wild-type and displays typical photosensitivity to high light intensities associated with phylloquinone deficiency in cyanobacteria Synechocystis sp.
physiological function the reaction is involved in phylloquinone (vitamin K1) biosynthesis Synechocystis sp.