BRENDA - Enzyme Database show
show all sequences of 3.1.2.22

Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function

Saja, S.; Buff, H.; Smith, A.C.; Williams, T.S.; Korey, C.A.; Neurobiol. Dis. 40, 135-145 (2010)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
Drosophila C-terminal Src kinase is an enhancer of the Ppt1 phenotype. Mutations in the fear of intimacy gene are also identified as enhancers. Mutations in zipper or mutations at the Drosophila IGF-II mRNA-binding protein locus enhance the degenerative phenotype. The tsg alleles tsg2 and tsg4 both enhance the rough eye phenotype produced by Ppt1 expression
Drosophila sp. (in: Insecta)
Cloned(Commentary)
Commentary
Organism
construction of a UAS:GFP-Ppt1 transgenic fly line. The pUAST:GFP-Ppt1 vector overexpressed using Act5C-Gal4
Drosophila sp. (in: Insecta)
overexpressed in Drosophila melanogaster
Drosophila melanogaster
Engineering
Amino acid exchange
Commentary
Organism
A179T
loss-of-function allele
Drosophila melanogaster
A179T
loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes
Drosophila sp. (in: Insecta)
S77F
loss-of-function allele
Drosophila melanogaster
S77F
loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes
Drosophila sp. (in: Insecta)
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
dSmt3 mutations are the lone suppressor modifiers
Drosophila sp. (in: Insecta)
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Drosophila melanogaster
-
-
-
Drosophila sp. (in: Insecta)
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
eye
-
Drosophila sp. (in: Insecta)
-
larva
-
Drosophila sp. (in: Insecta)
-
additional information
Garland cell
Drosophila sp. (in: Insecta)
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
-
710070
Drosophila sp. (in: Insecta)
?
-
-
-
?
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
4MU-6S-palm-beta-Glc
710070
Drosophila melanogaster
?
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
Drosophila C-terminal Src kinase is an enhancer of the Ppt1 phenotype. Mutations in the fear of intimacy gene are also identified as enhancers. Mutations in zipper or mutations at the Drosophila IGF-II mRNA-binding protein locus enhance the degenerative phenotype. The tsg alleles tsg2 and tsg4 both enhance the rough eye phenotype produced by Ppt1 expression
Drosophila sp. (in: Insecta)
Cloned(Commentary) (protein specific)
Commentary
Organism
overexpressed in Drosophila melanogaster
Drosophila melanogaster
construction of a UAS:GFP-Ppt1 transgenic fly line. The pUAST:GFP-Ppt1 vector overexpressed using Act5C-Gal4
Drosophila sp. (in: Insecta)
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
A179T
loss-of-function allele
Drosophila melanogaster
A179T
loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes
Drosophila sp. (in: Insecta)
S77F
loss-of-function allele
Drosophila melanogaster
S77F
loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes
Drosophila sp. (in: Insecta)
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
dSmt3 mutations are the lone suppressor modifiers
Drosophila sp. (in: Insecta)
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
eye
-
Drosophila sp. (in: Insecta)
-
larva
-
Drosophila sp. (in: Insecta)
-
additional information
Garland cell
Drosophila sp. (in: Insecta)
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
-
710070
Drosophila sp. (in: Insecta)
?
-
-
-
?
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
4MU-6S-palm-beta-Glc
710070
Drosophila melanogaster
?
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
Garland cells from Ppt1 loss-of-function mutants have defects in endocytic trafficking
Drosophila sp. (in: Insecta)
physiological function
Ppt1 plays a role in modulating the early stages of vesicle formation. There may be a connection between Ppt1 and bone morphogenetic protein signaling at the cellular level. Expression of wild-type Ppt1 in the adult visual system using GMR-Gal4 alters the external and internal organization of the adult retina. When co-expressed UAS-dynamin with Ppt1 there is a significant enhancement of the rough eye phenotype
Drosophila sp. (in: Insecta)
General Information (protein specific)
General Information
Commentary
Organism
malfunction
Garland cells from Ppt1 loss-of-function mutants have defects in endocytic trafficking
Drosophila sp. (in: Insecta)
physiological function
Ppt1 plays a role in modulating the early stages of vesicle formation. There may be a connection between Ppt1 and bone morphogenetic protein signaling at the cellular level. Expression of wild-type Ppt1 in the adult visual system using GMR-Gal4 alters the external and internal organization of the adult retina. When co-expressed UAS-dynamin with Ppt1 there is a significant enhancement of the rough eye phenotype
Drosophila sp. (in: Insecta)
Other publictions for EC 3.1.2.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
729768
Aby
Mutations in palmitoyl-protein ...
Drosophila melanogaster
Fly
7
267-279
2014
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1
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730430
Liu
Palmitoyl-protein thioesterase ...
Rattus norvegicus
Mol. Reprod. Dev.
81
55-65
2014
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1
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1
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730399
Hu
Intravenous high-dose enzyme r ...
Mus musculus
Mol. Genet. Metab.
107
213-221
2012
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1
1
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709975
Lu
Human recombinant palmitoyl-pr ...
Homo sapiens
Mol. Genet. Metab.
99
374-378
2010
-
1
1
-
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-
-
-
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4
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1
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2
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1
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-
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-
1
1
-
-
-
710070
Saja
Identifying cellular pathways ...
Drosophila melanogaster, Drosophila sp. (in: Insecta)
Neurobiol. Dis.
40
135-145
2010
1
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2
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4
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1
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3
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2
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2
2
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716234
Sanders
A mutation in canine PPT1 caus ...
Canis lupus familiaris
Mol. Genet. Metab.
100
349-356
2010
-
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-
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3
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1
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1
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1
1
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716683
Chu-LaGraff
The Batten disease Palmitoyl P ...
Drosophila melanogaster
PLoS ONE
5
e14402
2010
-
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1
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4
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1
1
-
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-
707548
Hirano
Thioesterase activity and subc ...
Homo sapiens
Biochim. Biophys. Acta
1791
797-805
2009
-
-
1
-
1
-
2
2
1
1
1
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2
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1
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1
2
1
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1
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1
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2
1
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1
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2
1
2
1
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1
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707557
Tardy
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1793
1250-1258
2009
-
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1
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4
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2
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2
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-
-
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-
4
4
-
-
-
708433
Macauley
Cerebellar pathology and motor ...
Mus musculus
Exp. Neurol.
217
124-135
2009
-
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2
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2
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1
1
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-
692414
Bannan
The Drosophila protein palmito ...
Drosophila melanogaster
Fly
2
198-214
2008
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1
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1
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2
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1
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693353
Kim
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
J. Clin. Invest.
118
3075-3086
2008
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1
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6
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4
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4
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4
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4
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1
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6
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4
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4
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707922
Takano
Infantile neuronal ceroid lipo ...
Homo sapiens
Brain Dev.
30
370-373
2008
-
1
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2
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1
1
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678930
Lyly
Glycosylation, transport, and ...
Homo sapiens
BMC Cell Biol.
8
22
2007
-
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4
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1
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680026
Buff
Genetic modifiers of Drosophil ...
Drosophila sp. (in: Insecta)
Genetics
176
209-220
2007
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664616
Kohan
Palmitoyl protein thioesterase ...
Homo sapiens
Clin. Biochem.
38
492-494
2005
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1
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665136
Zhang
Palmitoyl-protein thioesterase ...
Mus musculus
Hum. Mol. Genet.
15
337-346
2005
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666135
Porter
Identification and characteriz ...
Caenorhabditis elegans
J. Neurosci. Res.
79
836-848
2005
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651030
Cho
pdf1, a palmitoyl protein thio ...
Schizosaccharomyces pombe
Eukaryot. Cell
3
302-310
2004
-
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1
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1
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1
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2
1
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5
-
1
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1
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2
1
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1
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2
1
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650862
Lukacs
Rapid and simple assay for the ...
Homo sapiens
Clin. Chem.
49
509-512
2003
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1
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1
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1
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1
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1
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1
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3
1
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3
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1
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1
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652459
Calero
The crystal structure of palmi ...
Homo sapiens
J. Biol. Chem.
278
37957-37964
2003
-
-
1
1
1
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1
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1
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2
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1
1
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6
-
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1
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1
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1
1
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