Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Drosophila C-terminal Src kinase is an enhancer of the Ppt1 phenotype. Mutations in the fear of intimacy gene are also identified as enhancers. Mutations in zipper or mutations at the Drosophila IGF-II mRNA-binding protein locus enhance the degenerative phenotype. The tsg alleles tsg2 and tsg4 both enhance the rough eye phenotype produced by Ppt1 expression | Drosophila sp. (in: flies) |
Cloned (Comment) | Organism |
---|---|
construction of a UAS:GFP-Ppt1 transgenic fly line. The pUAST:GFP-Ppt1 vector overexpressed using Act5C-Gal4 | Drosophila sp. (in: flies) |
overexpressed in Drosophila melanogaster | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
A179T | loss-of-function allele | Drosophila melanogaster |
A179T | loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes | Drosophila sp. (in: flies) |
S77F | loss-of-function allele | Drosophila melanogaster |
S77F | loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes | Drosophila sp. (in: flies) |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | dSmt3 mutations are the lone suppressor modifiers | Drosophila sp. (in: flies) |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Drosophila sp. (in: flies) | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Drosophila sp. (in: flies) | - |
larva | - |
Drosophila sp. (in: flies) | - |
additional information | Garland cell | Drosophila sp. (in: flies) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O | - |
Drosophila sp. (in: flies) | 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate | - |
? | |
4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O | 4MU-6S-palm-beta-Glc | Drosophila melanogaster | 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
palmitoyl-protein thioesterase 1 | - |
Drosophila melanogaster |
palmitoyl-protein thioesterase 1 | - |
Drosophila sp. (in: flies) |
PPT1 | - |
Drosophila sp. (in: flies) |
General Information | Comment | Organism |
---|---|---|
malfunction | Garland cells from Ppt1 loss-of-function mutants have defects in endocytic trafficking | Drosophila sp. (in: flies) |
physiological function | Ppt1 plays a role in modulating the early stages of vesicle formation. There may be a connection between Ppt1 and bone morphogenetic protein signaling at the cellular level. Expression of wild-type Ppt1 in the adult visual system using GMR-Gal4 alters the external and internal organization of the adult retina. When co-expressed UAS-dynamin with Ppt1 there is a significant enhancement of the rough eye phenotype | Drosophila sp. (in: flies) |