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Literature summary for 3.1.2.22 extracted from

  • Ahtiainen, L.; Van Diggelen, O.P.; Jalanko, A.; Kopra, O.
    Palmitoyl protein thioesterase 1 is targeted to the axons in neurons (2003), J. Comp. Neurol., 455, 368-377.
    View publication on PubMed
Search for more literature for 3.1.2.22

Localization

Localization Comment Organism GeneOntology No. Textmining
axon preferably targeted to in mature neurons Mus musculus 30424
-
synaptic vesicle
-
 Mus musculus 8021
-
synaptosome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PPT1 deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, only in neurons of the cerebral and cerbellar cortexes and retina not in other cell types, characterized by early loss of vision and massiv neuronal death ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 PPT1
-

Reaction

Reaction Comment Organism Reaction ID
palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
epithelium retinal Mus musculus
-
eye
-
 Mus musculus
-
additional information activity is increased during neuronal maturation Mus musculus
-
neuron hippocampal, retinal, and cortical neurons Mus musculus
-
retina
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O artificial substrate Mus musculus 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
 ?
additional information PPT1 deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, only in neurons of the cerebral and cerbellar cortexes and retina not in other cell types, characterized by early loss of vision and massiv neuronal death Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
palmitoyl protein thioesterase 1
-
 Mus musculus
PPT1
-
 Mus musculus