BRENDA - Enzyme Database show
show all sequences of 3.1.2.22

pdf1, a palmitoyl protein thioesterase 1 ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease

Cho, S.K.; Hofmann, S.L.; Eukaryot. Cell 3, 302-310 (2004)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
DNA sequence determination and analysis, enzyme is encoded in frame with a second gene coding for an indispensable dolichol pyrophosphatase, gene pdf1, strains bearing a deletion of the entire pdf1 open reading frame are nonviable, due to Dolpp1p deficiency, and are rescued by pdf1 expression plasmid, mutations only in the palmitoyl protein thioesterase 1 domain results in cells abnormally sensitive to sodium vanadate and elevated extracellular pH, the pdf1-deficient phenotype is complemented by the human PPT1 gene
Schizosaccharomyces pombe
Inhibitors
Inhibitors
Commentary
Organism
Structure
Sodium vanadate
pdf1 mutant
Schizosaccharomyces pombe
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Schizosaccharomyces pombe
5764
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
101000
-
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Schizosaccharomyces pombe
PPT1 mutations cause severe neurodegenerative storage disorder, termed infantile Batten, in humans, Schizosaccharomyces pombe is a genetically tractable model for the sutdy of this disease due to evolutionary highly conserved gene and function
?
-
Schizosaccharomyces pombe
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Schizosaccharomyces pombe
O59747
cosmid; isozyme PPT1. gene pdf1
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
proteolytic modification
enzyme contains 2 putative cleavage sites for the kex-related endopeptidase Krp1p, the precursor is proteolytically processed to form distinct Ppt1p and Dolpp1p domains, Arg354 is crucial for the processing
Schizosaccharomyces pombe
Reaction
Reaction
Commentary
Organism
palmitoyl[protein] + H2O = palmitate + protein
specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA
Schizosaccharomyces pombe
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
artificial substrate
651030
Schizosaccharomyces pombe
4-methylumbelliferol + palmitate + beta-D-glucose
-
651030
Schizosaccharomyces pombe
?
additional information
PPT1 mutations cause severe neurodegenerative storage disorder, termed infantile Batten, in humans, Schizosaccharomyces pombe is a genetically tractable model for the sutdy of this disease due to evolutionary highly conserved gene and function
651030
Schizosaccharomyces pombe
?
-
651030
Schizosaccharomyces pombe
?
Subunits
Subunits
Commentary
Organism
?
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA sequence determination and analysis, enzyme is encoded in frame with a second gene coding for an indispensable dolichol pyrophosphatase, gene pdf1, strains bearing a deletion of the entire pdf1 open reading frame are nonviable, due to Dolpp1p deficiency, and are rescued by pdf1 expression plasmid, mutations only in the palmitoyl protein thioesterase 1 domain results in cells abnormally sensitive to sodium vanadate and elevated extracellular pH, the pdf1-deficient phenotype is complemented by the human PPT1 gene
Schizosaccharomyces pombe
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Sodium vanadate
pdf1 mutant
Schizosaccharomyces pombe
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Schizosaccharomyces pombe
5764
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
101000
-
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Schizosaccharomyces pombe
PPT1 mutations cause severe neurodegenerative storage disorder, termed infantile Batten, in humans, Schizosaccharomyces pombe is a genetically tractable model for the sutdy of this disease due to evolutionary highly conserved gene and function
?
-
Schizosaccharomyces pombe
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
proteolytic modification
enzyme contains 2 putative cleavage sites for the kex-related endopeptidase Krp1p, the precursor is proteolytically processed to form distinct Ppt1p and Dolpp1p domains, Arg354 is crucial for the processing
Schizosaccharomyces pombe
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-methylumbelliferyl-6-thiopalmitoyl-beta-D-glucoside + H2O
artificial substrate
651030
Schizosaccharomyces pombe
4-methylumbelliferol + palmitate + beta-D-glucose
-
651030
Schizosaccharomyces pombe
?
additional information
PPT1 mutations cause severe neurodegenerative storage disorder, termed infantile Batten, in humans, Schizosaccharomyces pombe is a genetically tractable model for the sutdy of this disease due to evolutionary highly conserved gene and function
651030
Schizosaccharomyces pombe
?
-
651030
Schizosaccharomyces pombe
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 31000, processed enzyme, SDS-PAGE, x * 101000, unprocessed enzyme, SDS-PAGE
Schizosaccharomyces pombe
Other publictions for EC 3.1.2.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
729768
Aby
Mutations in palmitoyl-protein ...
Drosophila melanogaster
Fly
7
267-279
2014
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1
1
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730430
Liu
Palmitoyl-protein thioesterase ...
Rattus norvegicus
Mol. Reprod. Dev.
81
55-65
2014
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1
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1
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1
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730399
Hu
Intravenous high-dose enzyme r ...
Mus musculus
Mol. Genet. Metab.
107
213-221
2012
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1
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1
1
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709975
Lu
Human recombinant palmitoyl-pr ...
Homo sapiens
Mol. Genet. Metab.
99
374-378
2010
-
1
1
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4
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1
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1
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1
1
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710070
Saja
Identifying cellular pathways ...
Drosophila melanogaster, Drosophila sp. (in: Insecta)
Neurobiol. Dis.
40
135-145
2010
1
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2
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4
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1
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2
2
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716234
Sanders
A mutation in canine PPT1 caus ...
Canis lupus familiaris
Mol. Genet. Metab.
100
349-356
2010
-
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3
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1
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1
1
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716683
Chu-LaGraff
The Batten disease Palmitoyl P ...
Drosophila melanogaster
PLoS ONE
5
e14402
2010
-
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1
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1
1
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707548
Hirano
Thioesterase activity and subc ...
Homo sapiens
Biochim. Biophys. Acta
1791
797-805
2009
-
-
1
-
1
-
2
2
1
1
1
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1
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1
2
1
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1
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707557
Tardy
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1793
1250-1258
2009
-
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1
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4
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2
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4
4
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708433
Macauley
Cerebellar pathology and motor ...
Mus musculus
Exp. Neurol.
217
124-135
2009
-
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2
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1
1
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692414
Bannan
The Drosophila protein palmito ...
Drosophila melanogaster
Fly
2
198-214
2008
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1
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693353
Kim
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
J. Clin. Invest.
118
3075-3086
2008
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1
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6
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4
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4
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6
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707922
Takano
Infantile neuronal ceroid lipo ...
Homo sapiens
Brain Dev.
30
370-373
2008
-
1
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678930
Lyly
Glycosylation, transport, and ...
Homo sapiens
BMC Cell Biol.
8
22
2007
-
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4
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1
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1
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680026
Buff
Genetic modifiers of Drosophil ...
Drosophila sp. (in: Insecta)
Genetics
176
209-220
2007
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664616
Kohan
Palmitoyl protein thioesterase ...
Homo sapiens
Clin. Biochem.
38
492-494
2005
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665136
Zhang
Palmitoyl-protein thioesterase ...
Mus musculus
Hum. Mol. Genet.
15
337-346
2005
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666135
Porter
Identification and characteriz ...
Caenorhabditis elegans
J. Neurosci. Res.
79
836-848
2005
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651030
Cho
pdf1, a palmitoyl protein thio ...
Schizosaccharomyces pombe
Eukaryot. Cell
3
302-310
2004
-
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1
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1
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1
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5
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650862
Lukacs
Rapid and simple assay for the ...
Homo sapiens
Clin. Chem.
49
509-512
2003
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1
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1
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652459
Calero
The crystal structure of palmi ...
Homo sapiens
J. Biol. Chem.
278
37957-37964
2003
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1
1
1
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1
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1
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2
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1
1
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6
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