BRENDA - Enzyme Database show
show all sequences of 3.1.2.22

The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function

Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.; Biochim. Biophys. Acta 1583, 35-44 (2002)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Chloroquine
inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells
Homo sapiens
leupeptin
inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells but has no direct inhibitory effect on the enzyme
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder
?
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Reaction
Reaction
Commentary
Organism
palmitoyl[protein] + H2O = palmitate + protein
specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
B-lymphoblastoid cell line
transformed by Epstein-Barr virus
Homo sapiens
-
brain
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder
650368
Homo sapiens
?
-
650368
Homo sapiens
?
palmitoyl-[protein] + H2O
-
650368
Homo sapiens
palmitate + protein
-
650368
Homo sapiens
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Chloroquine
inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells
Homo sapiens
leupeptin
inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells but has no direct inhibitory effect on the enzyme
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder
?
-
Homo sapiens
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
B-lymphoblastoid cell line
transformed by Epstein-Barr virus
Homo sapiens
-
brain
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder
650368
Homo sapiens
?
-
650368
Homo sapiens
?
palmitoyl-[protein] + H2O
-
650368
Homo sapiens
palmitate + protein
-
650368
Homo sapiens
?
Other publictions for EC 3.1.2.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Aby
Mutations in palmitoyl-protein ...
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7
267-279
2014
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1
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730430
Liu
Palmitoyl-protein thioesterase ...
Rattus norvegicus
Mol. Reprod. Dev.
81
55-65
2014
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730399
Hu
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Mus musculus
Mol. Genet. Metab.
107
213-221
2012
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1
1
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709975
Lu
Human recombinant palmitoyl-pr ...
Homo sapiens
Mol. Genet. Metab.
99
374-378
2010
-
1
1
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1
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-
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1
1
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710070
Saja
Identifying cellular pathways ...
Drosophila melanogaster, Drosophila sp. (in: Insecta)
Neurobiol. Dis.
40
135-145
2010
1
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2
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4
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1
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2
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716234
Sanders
A mutation in canine PPT1 caus ...
Canis lupus familiaris
Mol. Genet. Metab.
100
349-356
2010
-
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1
1
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716683
Chu-LaGraff
The Batten disease Palmitoyl P ...
Drosophila melanogaster
PLoS ONE
5
e14402
2010
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1
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4
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1
1
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707548
Hirano
Thioesterase activity and subc ...
Homo sapiens
Biochim. Biophys. Acta
1791
797-805
2009
-
-
1
-
1
-
2
2
1
1
1
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2
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1
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2
1
2
1
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1
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2
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1
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1
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2
2
1
1
1
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1
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2
1
2
1
-
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1
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707557
Tardy
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1793
1250-1258
2009
-
-
1
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-
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4
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2
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4
4
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708433
Macauley
Cerebellar pathology and motor ...
Mus musculus
Exp. Neurol.
217
124-135
2009
-
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1
1
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692414
Bannan
The Drosophila protein palmito ...
Drosophila melanogaster
Fly
2
198-214
2008
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693353
Kim
Palmitoyl protein thioesterase ...
Homo sapiens, Mus musculus
J. Clin. Invest.
118
3075-3086
2008
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1
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6
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4
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4
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707922
Takano
Infantile neuronal ceroid lipo ...
Homo sapiens
Brain Dev.
30
370-373
2008
-
1
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678930
Lyly
Glycosylation, transport, and ...
Homo sapiens
BMC Cell Biol.
8
22
2007
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4
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1
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680026
Buff
Genetic modifiers of Drosophil ...
Drosophila sp. (in: Insecta)
Genetics
176
209-220
2007
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664616
Kohan
Palmitoyl protein thioesterase ...
Homo sapiens
Clin. Biochem.
38
492-494
2005
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1
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665136
Zhang
Palmitoyl-protein thioesterase ...
Mus musculus
Hum. Mol. Genet.
15
337-346
2005
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666135
Porter
Identification and characteriz ...
Caenorhabditis elegans
J. Neurosci. Res.
79
836-848
2005
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651030
Cho
pdf1, a palmitoyl protein thio ...
Schizosaccharomyces pombe
Eukaryot. Cell
3
302-310
2004
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650862
Lukacs
Rapid and simple assay for the ...
Homo sapiens
Clin. Chem.
49
509-512
2003
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1
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1
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652459
Calero
The crystal structure of palmi ...
Homo sapiens
J. Biol. Chem.
278
37957-37964
2003
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-
1
1
1
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1
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1
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2
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1
1
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6
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1
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1
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1
1
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1
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1
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6
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1
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652624
Ahtiainen
Palmitoyl protein thioesterase ...
Mus musculus
J. Comp. Neurol.
455
368-377
2003
-
-
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-
-
3
-
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1
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1
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1
-
6
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2
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3
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6
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650368
Lu
The effects of lysosomotropic ...
Homo sapiens
Biochim. Biophys. Acta
1583
35-44
2002
-
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2
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1
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2
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1
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653345
Suopanki
Status epilepticus induces cha ...
Rattus norvegicus
Neurobiol. Dis.
10
247-257
2002
-
-
-
-
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