Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + H2O | Mus musculus | - |
CoA + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8VHQ9 | - |
- |
Mus musculus | Q91V12 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brown adipose tissue | - |
Mus musculus | - |
duodenum | - |
Mus musculus | - |
gonad | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
plantaris muscle | - |
Mus musculus | - |
soleus | - |
Mus musculus | - |
white adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + H2O | - |
Mus musculus | CoA + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACOT | - |
Mus musculus |
Acot11 | isoform | Mus musculus |
Acot7 | isoform | Mus musculus |
acyl-CoA thioesterase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | isoform Acot11 is up-regulated in adipose and liver during conditions that increase lipid anabolic processes, specifically Acot11 is up-regulated 10 and 34fold in FR (control diet fed mice fasted for 14 hours then refed for 12 hours overnight) gonadal white adipose tissue and inguinal white adipose tissue, respectively, and 5fold and 13fold in liver during FR and high-fat diet, respectively | up |
General Information | Comment | Organism |
---|---|---|
physiological function | doubling cytosolic enzyme activity fails to protect mice from diet-induced obesity, fatty liver or insulin resistance, however, overexpression of isoform Acot7 in adipocytes renders mice cold intolerant | Mus musculus |