Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.2.20 extracted from

  • Moffat, C.; Bhatia, L.; Nguyen, T.; Lynch, P.; Wang, M.; Wang, D.; Ilkayeva, O.R.; Han, X.; Hirschey, M.D.; Claypool, S.M.; Seifert, E.L.
    Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver (2014), J. Lipid Res., 55; 2458-2470, 2458-2470.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.2.20

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linolenoyl-CoA + H2O
-
 Mus musculus CoA + linolenoate
-
 ?
myristoyl-CoA + H2O
-
 Mus musculus CoA + myristate
-
 ?
oleoyl-CoA + H2O
-
 Mus musculus CoA + oleate
-
 ?
palmitoyl-CoA + H2O
-
 Mus musculus CoA + palmitate
-
 ?

Synonyms

Synonyms Comment Organism
ACOT2
-
 Mus musculus
acyl-CoA thioesterase-2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction Ad-Acot2 mice have higher free fatty acid utilization during the rest phase of the day but readily switch to carbohydrate oxidation at night. In isolated Ad-Acot2 liver mitochondria, phosphorylating O2 consumption is elevated with lipid but not non-lipid substrate. While the monolysocardiolipin pool in expanded in Ad-Acot2 liver mitochondria, total cardiolipin is unchanged Mus musculus
metabolism Acot2 enhances mitochondrial fatty acid oxidation Mus musculus