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Literature summary for 3.1.2.20 extracted from

  • Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.
    Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs (2006), FASEB J., 20, 1855-1864.
    View publication on PubMed
Search for more literature for 3.1.2.20

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
 succinyl-CoA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q3I5F7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart weak expression Homo sapiens
-
kidney strongest expression in liver and kidney Homo sapiens
-
liver strongest expression in liver and kidney Homo sapiens
-
muscle weak expression Homo sapiens
-
placenta weak expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dodecanoyl-CoA + H2O
-
 Homo sapiens CoA + dodecanoate
-
 ?
eicosanoyl-CoA + H2O
-
 Homo sapiens CoA + eicosanoic acid
-
 ?
hexadecanoyl-CoA + H2O
-
 Homo sapiens CoA + hexadecanoate
-
 ?
additional information ACOT4 protein is active on succinyl-CoA and medium to long chain acyl-CoAs. Human ACOT4 gene has acquired the functions of three mouse genes by a functional convergent evolution Homo sapiens ?
-
 ?
octadecanoyl-CoA + H2O
-
 Homo sapiens CoA + octadecanoate
-
 ?
succinyl-CoA + H2O
-
 Homo sapiens CoA + succinate
-
 ?
tetradecanoyl-CoA + H2O
-
 Homo sapiens CoA + tetradecanoate
-
 ?

Synonyms

Synonyms Comment Organism
ACOT4
-
 Homo sapiens
acyl-CoA thioesterase
-
 Homo sapiens