Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor diffusion in 20% PEG 2000. Crystal structures of both the N- and C-terminal domains of the mouse enzyme. The quaternary arrangement in Acot7 features a trimer of hotdog fold dimers | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D213A | mutation results in a strong reduction in catalytic activity | Mus musculus |
E39A | mutation does not affect activity | Mus musculus |
E39D/T198N | mutant displays a 4fold increase in the catalytic activity compared with wild-type Acot7 | Mus musculus |
N24A | mutation results in a strong reduction in catalytic activity | Mus musculus |
T198A | mutation does not affect activity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | role in eicosanoid synthesis and inflammation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91V12 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | up-regulated by lipopolysaccharide and that overexpression of Acot7 in a macrophage cell line alters the production of prostaglandins D2 and E2 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonoyl-CoA + H2O | - |
Mus musculus | CoA + arachidonate | - |
? | |
lauroyl-CoA + H2O | - |
Mus musculus | CoA + laurate | - |
? | |
additional information | role in eicosanoid synthesis and inflammation | Mus musculus | ? | - |
? | |
octanoyl-CoA + H2O | - |
Mus musculus | CoA + octanoate | - |
? | |
palmitoyl-CoA + H2O | - |
Mus musculus | CoA + palmitate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Acot7 | - |
Mus musculus |
acyl-CoA thioesterase 7 | - |
Mus musculus |