Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(tetradecylsulfanyl)acetic acid | stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview | Rattus norvegicus | |
3-(tetradecylsulfanyl)propanoic acid | stimulates palmitoyl-CoA, tetradecylthioacetyl-CoA and tetradecylthiopropionyl-CoA hydrolase activities in cytosol, mitochondrion and peroxisome, overview | Rattus norvegicus | |
additional information | no stimulation by tetradecylthiopropionate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-(decane-1,10-diyldisulfanediyl)diacetic acid | palmitoyl-CoA hydrolase activity, L-fraction and peroxisomes, especially of 3-thia fatty acids treated rats | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
microsome | - |
Rattus norvegicus | - |
- |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
additional information | substrate specificities in different subcellular fractions | Rattus norvegicus | - |
- |
peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hexadecanoyl-CoA + H2O | Rattus norvegicus | i.e. palmitoyl-CoA | CoA + hexadecanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | of rats treated with 3-thia fatty acids, i.e. tetradecylthioacetic acid and 3-dithiacarboxylic acid | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities in different subcellular fractions with different substrates after induction with 3-thia fatty acids, overview | Rattus norvegicus |
0.039 | - |
post-nuclear fraction, substrate tetradecylthiopropionyl-CoA | Rattus norvegicus |
0.044 | - |
post-nuclear fraction, substrate palmitoyl-CoA | Rattus norvegicus |
0.057 | - |
post-nuclear fraction, substrate tetradecylthioacetyl-CoA | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + H2O | - |
Rattus norvegicus | CoA + a carboxylate | - |
? | |
hexadecanoyl-CoA + H2O | i.e. palmitoyl-CoA | Rattus norvegicus | CoA + hexadecanoate | - |
? | |
tetradecylthioacetyl-CoA + H2O | best substrate | Rattus norvegicus | CoA + tetradecylthioacetate | - |
? | |
tetradecylthiopropionyl-CoA + H2O | - |
Rattus norvegicus | CoA + tetradecylthiopropionate | - |
? |