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Literature summary for 3.1.2.18 extracted from
- NADH-sensitive propionyl-CoA hydrolase in brown adipose tissue mitochondria of the rat (1989), Biochim. Biophys. Acta, 1005, 13-19.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | cold acclimation induces enzyme activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| beta-NADH | 91% inhibition at 0.4 mM; regulatory function | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial matrix | - |
Rattus norvegicus | 5759 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| additional information | submitochondrial and subcellular distribution | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 240000 | - |
at least, gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + H2O | Rattus norvegicus | - |
CoA + a carboxylate | - |
? | |
| propionyl-CoA + H2O | Rattus norvegicus | ensures that the propionyl-CoA level in mitochondria is not detrimentally increased | CoA + propionate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
adult femal Sprague-Dawley rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brown adipose tissue | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + H2O | low activity | Rattus norvegicus | acetate + CoA | - |
? | |
| acyl-CoA + H2O | - |
Rattus norvegicus | CoA + a carboxylate | - |
? | |
| propionyl-CoA + H2O | best substrate | Rattus norvegicus | CoA + propionate | - |
? | |
| propionyl-CoA + H2O | ensures that the propionyl-CoA level in mitochondria is not detrimentally increased | Rattus norvegicus | CoA + propionate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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