Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cold acclimation induces enzyme activity | Mesocricetus auratus | |
additional information | no activation by ATP or AMP | Mesocricetus auratus |
General Stability | Organism |
---|---|
ADP stabilizes | Mesocricetus auratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP | inhibitory at high concentration | Mesocricetus auratus | |
ATP | inhibitory at high concentration | Mesocricetus auratus | |
beta-NADH | stereospecific: not alpha-NADH, reversible by ADP or Ca2+, not by Mg2+ | Mesocricetus auratus | |
Cd2+ | - |
Mesocricetus auratus | |
additional information | no inhibition by alpha-NADH, NADPH, NAD+, EDTA or EGTA | Mesocricetus auratus | |
Ni2+ | - |
Mesocricetus auratus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
ADP | pH 7.4, 25°C | Mesocricetus auratus | |
0.3 | - |
Ca2+ | pH 7.4, 25°C | Mesocricetus auratus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | submitochondrial distribution | Mesocricetus auratus | 5759 | - |
mitochondrion | - |
Mesocricetus auratus | 5739 | - |
additional information | submitochondrial and subcellular distribution | Mesocricetus auratus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation, Km-value: 0.3 mM | Mesocricetus auratus | |
K+ | activation | Mesocricetus auratus | |
Mg2+ | activation | Mesocricetus auratus | |
additional information | no activation by Na+ | Mesocricetus auratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + H2O | Mesocricetus auratus | - |
CoA + a carboxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
Syrian hamster, adult female, acclimated to cold | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mesocricetus auratus | - |
additional information | not in liver tissue | Mesocricetus auratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + H2O | - |
Mesocricetus auratus | CoA + a carboxylate | - |
? | |
malonyl-CoA + H2O | very poor substrate | Mesocricetus auratus | malonate + CoA | - |
? | |
propionyl-CoA + H2O | best substrate | Mesocricetus auratus | CoA + propionate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mesocricetus auratus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
t1/2: 1 min, in buffer with Triton X-100 but without substrates, decrease of activity in intact mitochondria, ADP stabilizes: t1/2: 1 h, substrates protect | Mesocricetus auratus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | requirement | Mesocricetus auratus |