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Literature summary for 3.1.2.12 extracted from

  • Li, W.; Zhu, Z.; Cao, W.; Yang, F.; Zhang, X.; Li, D.; Zhang, K.; Li, P.; Mao, R.; Liu, X.; Zheng, H.
    Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication (2016), Mol. Immunol., 75, 112-121 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Sus scrofa Q9GJT2
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-

Synonyms

Synonyms Comment Organism
ESD
-
Sus scrofa

Expression

Organism Comment Expression
Sus scrofa foot-and-mouth disease virus infection triggers ESD expression up

General Information

General Information Comment Organism
physiological function overexpression of ESD significantly suppresses foot-and-mouth disease virus FMDV replication. Knockdown of ESD expression enhances virus replication. Sendai-virus-induced interferon signaling is enhanced by upregulation of ESD. ESD protein enhances IRF3 phosphorylation during FMDV infection. Overexpression of ESD also promotes the expression of various antiviral interferon-stimulated genes, and knockdown of ESD impairs the expression of these antiviral genes during FMDV infection Sus scrofa