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Literature summary for 3.1.2.11 extracted from
- A survey of enzymes which generate or use acetoacetyl thioesters in rat liver (1983), J. Biol. Chem., 258, 4725-4733.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cysteine | stimulation | Rattus norvegicus |  |
| dithiothreitol | stimulation | Rattus norvegicus | |
| glutathione | stimulation | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
acetoacetyl-CoA | liver cytosol, absence of glutathione | Rattus norvegicus | |
| 0.025 | - |
acetoacetyl-CoA | liver cytosol, presence of glutathione | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetoacetyl-CoA + H2O | - |
Rattus norvegicus | acetoacetate + CoA | - |
? | |
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