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Literature summary for 3.1.2.1 extracted from

  • Laurieri, N.; Dairou, J.; Egleton, J.E.; Stanley, L.A.; Russell, A.J.; Dupret, J.M.; Sim, E.; Rodrigues-Lima, F.
    From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2 (2014), PLoS ONE, 9, e96370.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
naphthoquinone
-
 Homo sapiens
naphthoquinone
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + H2O = CoA + acetate as shown by proton nuclear magnetic resonance spectroscopy the disappearance of acetyl CH3 from acetyl Coenzyme A occurres concomitantly with the appearance of a CH3 peak corresponding to that of free acetate and suggesting that folate is not acetylated during the reaction Mus musculus
a
acetyl-CoA + H2O = CoA + acetate as shown by proton nuclear magnetic resonance spectroscopy the disappearance of acetyl CH3 from acetyl Coenzyme A occurrs concomitantly with the appearance of a CH3 peak corresponding to that of free acetate and suggesting that folate is not acetylated during the reaction Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O
-
 Mus musculus CoA + acetate
-
 ?
acetyl-CoA + H2O
-
 Homo sapiens CoA + acetate
-
 ?

Synonyms

Synonyms Comment Organism
(HUMN)NAT1
-
 Homo sapiens
(MOUSE)NAT2
-
 Mus musculus
human arylamine N-acetyltransferase Type 1
-
 Homo sapiens
mouse arylamine N-acetyltransferase Type 2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
folate folate binds at the enzyme's active site, and facilitate acetyl coenzyme A hydrolysis Mus musculus
folate folate binds at the enzyme's active site, and facilitate acetyl coenzyme A hydrolysis Homo sapiens