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Literature summary for 3.1.16.1 extracted from

  • Li, C.H.; Irmer, H.; Gudjonsdottir-Planck, D.; Freese, S.; Salm, H.; Haile, S.; Estevez, A.M.; Clayton, C.
    Roles of a Trypanosoma brucei 5->3 exoribonuclease homolog in mRNA degradation (2006), RNA, 12, 2171-2186.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.16.1

Application

Application Comment Organism
additional information XRNA and XRND are required for trypanosome growth Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged XRND protein expressed in Escherichia coli by cloning into pET3A vector Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
RNAi down-regulation of expression by tetracycline-inducible RNA interference Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm XRNA, XRNB and XRNC Trypanosoma brucei 5737
-
nucleus XRNA and XRND Trypanosoma brucei 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
 XRNC Trypanosoma brucei
115000
-
 XRNB Trypanosoma brucei
158000
-
 XRNA Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
XRND purified by nickel affinity chromatography Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining
additional information bloodstream forms and procyclic forms of trypanosomes Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mRNA + H2O XRNA is important in the degradation of deadenylated mRNAs in trypanosomes Trypanosoma brucei ?
-
 ?

Synonyms

Synonyms Comment Organism
5->3 exoribonuclease
-
 Trypanosoma brucei
XRNA
-
 Trypanosoma brucei
XRNB
-
 Trypanosoma brucei
XRNC
-
 Trypanosoma brucei
XRND
-
 Trypanosoma brucei