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Literature summary for 3.1.13.4 extracted from

  • Maragozidis, P.; Papanastasi, E.; Scutelnic, D.; Totomi, A.; Kokkori, I.; Zarogiannis, S.G.; Kerenidi, T.; Gourgoulianis, K.I.; Balatsos, N.A.
    Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer prognostic value and impact on gene expression (2015), Mol. Cancer, 14, 187 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
diagnostics clinical significance of deadenylases PARN and NOC on the survival in SCC diagnosed patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene PARN, quantitative real-time PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95453
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-
lung squamous cell carcinoma cell the expression of deadenylase PARN is differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age. Kaplan-Meier analysis suggests that increased levels of PARN correlates with significantly increased survival Homo sapiens
-
squamous cell lung cancer cell the expression of deadenylase PARN is differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age. Kaplan-Meier analysis suggests that increased levels of PARN correlates with significantly increased survival Homo sapiens
-

Synonyms

Synonyms Comment Organism
PARN
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of several deadenylases is altered in squamous cell lung cancer, SCC. Quantitative real-time PCR shows that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age and CNOT6 overexpression with non-metastatic tumors. Kaplan-Meier analysis suggests that increased levels of PARN and NOC correlate with significantly increased survival. The gene expression deregulation is functionally enriched for gene ontologies related to cell adhesion, cell junction, muscle contraction and metabolism up

General Information

General Information Comment Organism
metabolism the expression of several deadenylases is altered in squamous cell lung cancer, SCC. Quantitative real-time PCR shows that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in SCC clinical samples. PARN overexpression correlates with younger patient age and CNOT6 overexpression with non-metastatic tumors. Kaplan-Meier analysis suggests that increased levels of PARN and NOC correlate with significantly increased survival. The gene expression deregulation is functionally enriched for gene ontologies related to cell adhesion, cell junction, muscle contraction and metabolism Homo sapiens