Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | p21 3'-UTR triggers the action of PARN in the AGS cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene PARN, quantitative real-time PCR expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | stable knockdown of the endogenous PARN in the gastric cancer MKN28 and AGS cells. PARN depletion significantly inhibits the proliferation of the two types of gastric cancer cells and promotes cell death, but does not significantly affect cell motility and invasion. The depletion of PARN arrests the gastric cancer cells at the G0/G1 phase by upregulating the expression levels of p53 and p21 but not p27. The mRNA stability of p53 is unaffected by PARN-knockdown in both types of cells. A significant stabilizing effect of PARN-depletion on p21 mRNA is observed in the AGS cells but not in the MKN28 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95453 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | - |
Homo sapiens | - |
gastric cancer cell | poly(A)-specific ribonuclease (PARN) is upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS, determination of the expression level of PARN in human gastric cancer cells and tissues by quantitative real-time PCR expression analysis | Homo sapiens | - |
MKN-28 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PARN | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression. PARN depletion leads to cell cycle arrest by upregulating p21 expression, stabilizes the p21 mRNA (one of the key regulators in cell growth and survival), and promotes cell death, but does not affect the formation of RNA granules | Homo sapiens |
physiological function | the action of PARN strongly relies on protein expression profiles of the cells, which leads to heterogeneity in the stability of PARN-targeted mRNAs | Homo sapiens |