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Literature summary for 3.1.13.4 extracted from

  • Zhang, L.; Yan, Y.
    Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression (2015), Biochim. Biophys. Acta, 1853, 522-534 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information p21 3'-UTR triggers the action of PARN in the AGS cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene PARN, quantitative real-time PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stable knockdown of the endogenous PARN in the gastric cancer MKN28 and AGS cells. PARN depletion significantly inhibits the proliferation of the two types of gastric cancer cells and promotes cell death, but does not significantly affect cell motility and invasion. The depletion of PARN arrests the gastric cancer cells at the G0/G1 phase by upregulating the expression levels of p53 and p21 but not p27. The mRNA stability of p53 is unaffected by PARN-knockdown in both types of cells. A significant stabilizing effect of PARN-depletion on p21 mRNA is observed in the AGS cells but not in the MKN28 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95453
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
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gastric cancer cell poly(A)-specific ribonuclease (PARN) is upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS, determination of the expression level of PARN in human gastric cancer cells and tissues by quantitative real-time PCR expression analysis Homo sapiens
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MKN-28 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
PARN
-
Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression. PARN depletion leads to cell cycle arrest by upregulating p21 expression, stabilizes the p21 mRNA (one of the key regulators in cell growth and survival), and promotes cell death, but does not affect the formation of RNA granules Homo sapiens
physiological function the action of PARN strongly relies on protein expression profiles of the cells, which leads to heterogeneity in the stability of PARN-targeted mRNAs Homo sapiens