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Literature summary for 3.1.13.4 extracted from

  • Balatsos, N.A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C.
    Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides (2009), Biochemistry, 48, 6044-6051.
    View publication on PubMed
Search for more literature for 3.1.13.4

Cloned(Commentary)

Cloned (Comment) Organism
expressed as N-terminal His6-tagged polypeptide in Escherichia coli BL21(DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl) cytosine
-
 Homo sapiens
1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N4-benzoyl cytosine
-
 Homo sapiens
9-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N6-benzoyl adenine
-
 Homo sapiens
AMP
-
 Homo sapiens
CMP
-
 Homo sapiens
synthetic fluoro-pyranosyl nucleosides synthetic nucleoside analogues bearing a fluoroglucopyranosyl sugar moiety and benzoyl-modified cytosine or adenine as a base can effectively inhibit human PARN Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74000
-
 calculated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95453
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(A) + H2O
-
 Homo sapiens AMP
-
 ir

Synonyms

Synonyms Comment Organism
PARN
-
 Homo sapiens
poly(A)-specific ribonuclease
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.21
-
 1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N4-benzoyl cytosine at pH 7.0, 30°C Homo sapiens
0.51
-
 9-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl)-N6-benzoyl adenine at pH 7.0, 30°C Homo sapiens
0.645
-
 1-(3',4'-dideoxy-3'-fluoro-beta-D-glucopyranosyl) cytosine at pH 7.0, 30°C Homo sapiens
0.7
-
 CMP at pH 7.0, 30°C Homo sapiens
1.6
-
 AMP at pH 7.0, 30°C Homo sapiens