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Literature summary for 3.1.13.4 extracted from

  • Chen, J.; Chiang, Y.C.; Denis, C.L.
    CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase (2002), EMBO J., 21, 1414-1426.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.4

Protein Variants

Protein Variants Comment Organism
D713A significant reduction of enzymic activity Saccharomyces cerevisiae
D780A significant reduction of enzymic activity Saccharomyces cerevisiae
E556A complete loss of activity, E556 is the key Mg2+-binding residue Saccharomyces cerevisiae
H818A significant reduction of enzymic activity Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 enzyme contains both RNA and single-stranded DNA 3’-5’-exonuclease activities
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(A)-mRNA + H2O
-
 Saccharomyces cerevisiae 5'-AMP
-
 ?
poly(a)-ssDNA + H2O
-
 Saccharomyces cerevisiae 5'-dAMP
-
 ?

Synonyms

Synonyms Comment Organism
CCR4
-
 Saccharomyces cerevisiae
cytoplasmic deadenylase
-
 Saccharomyces cerevisiae