Literature summary for 3.1.13.2 extracted from

Fuji, H.; Urano, E.; Futahashi, Y.; Hamatake, M.; Tatsumi, J.; Hoshino, T.; Morikawa, Y.; Yamamoto, N.; Komano, J.
Derivatives of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester inhibit RNase H activity associated with HIV-1 reverse transcriptase (2009), J. Med. Chem., 52, 1380-1387.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester	derivative of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester	murine leukemia virus
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl] methyl ester	derivative of 5-nitrofuran-2-carboxylic acid carbamoyl methyl ester. 20-25 microM effectively inhibited HIV-1 replication	murine leukemia virus

Organism

Organism	UniProt	Comment	Textmining
murine leukemia virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA-RNA duplex + H2O	-	murine leukemia virus	?	-	?

Synonyms

Synonyms	Comment	Organism
RNase H	-	murine leukemia virus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0084	-	for murine leukemia virus reverse transcriptase, pH 7.8, 37°C	murine leukemia virus	5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester
0.0086	-	for murine leukemia virus reverse transcriptase	murine leukemia virus	5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl] methyl ester

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Release 2023.1 (January 2023)