G190A |
site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows reduced fitness compared to the wild-type enzyme |
Human immunodeficiency virus 1 |
G190S |
site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows highly reduced fitness compared to the wild-type enzyme |
Human immunodeficiency virus 1 |
K103N |
site-directed mutagenesis, the mutation confers resistance to non-nucleoside reverse transcriptase inhibitors, and leads to reduced RNase H activity of the reverse transcriptase and to reduced DNA synthesis from tRNALys,3 that correlate with reductions in replication efficiency, the mutant shows a fitness similar to the wild-type enzyme |
Human immunodeficiency virus 1 |