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Literature summary for 3.1.13.2 extracted from

  • Takada, K.; Bermingham, A.; OKeefe, B.R.; Wamiru, A.; Beutler, J.A.; Le Grice, S.F.; Lloyd, J.; Gustafson, K.R.; McMahon, J.B.
    An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis (2007), J. Nat. Prod., 70, 1647-1649.
    View publication on PubMed
Search for more literature for 3.1.13.2

Application

Application Comment Organism
drug development HIV-1 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications Human immunodeficiency virus 1
drug development HIV-2 RNase H is an attractive molecular target for developing anti-HIV agents for potential chemotherapeutic applications Human immunodeficiency virus 2

Inhibitors

Inhibitors Comment Organism Structure
1,3,4,5-tetragalloylapiitol isolated from the aqueous extract of leaves of the plant Hylodendron gabunensis Human immunodeficiency virus 1
1,3,4,5-tetragalloylapiitol isolated from the aqueous extract of leaves of the plant Hylodendron gabunensis Human immunodeficiency virus 2
additional information natural product extracts screening for detection of inhibitors specific for HIV-1 RNase H Human immunodeficiency virus 1
additional information natural product extracts screening for detection of inhibitors specific for HIV-2 RNase H Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human immunodeficiency virus 1 the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome ?
-
 ?
additional information Human immunodeficiency virus 2 the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-
Human immunodeficiency virus 2
-
 i.e. HIV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O RNase H specifically hydrolyzes the RNA strand of a RNA/DNA heteroduplex, the ribonuclease H hydrolytic activity is part of the reverse transcriptase Human immunodeficiency virus 1 ?
-
 ?
DNA-RNA hybrid + H2O RNase H specifically hydrolyzes the RNA strand of a RNA/DNA heteroduplex, the ribonuclease H hydrolytic activity is part of the reverse transcriptase Human immunodeficiency virus 2 ?
-
 ?
additional information the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome Human immunodeficiency virus 1 ?
-
 ?
additional information the RNase H function of HIV RT is required to effectively incorporate viral genetic information into the host cell genome Human immunodeficiency virus 2 ?
-
 ?

Synonyms

Synonyms Comment Organism
RNase H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 2

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Human immunodeficiency virus 1
25
-
 assay at Human immunodeficiency virus 2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00013
-
 25°C Human immunodeficiency virus 2 1,3,4,5-tetragalloylapiitol
0.00024
-
 25°C Human immunodeficiency virus 1 1,3,4,5-tetragalloylapiitol