Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.13.2 extracted from

  • Budihas, S.R.; Gorshkova, I.; Gaidamakov, S.; Wamiru, A.; Bona, M.K.; Parniak, M.A.; Crouch, R.J.; McMahon, J.B.; Beutler, J.A.; Le Grice, S.F.J.
    Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones (2005), Nucleic Acids Res., 33, 1249-1256.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of RNase H /reverse transcriptase from HIV-1 and HIV-2 in Escherichia coli Human Immunodeficiency Virus

Inhibitors

Inhibitors Comment Organism Structure
alpha-thujaplicin i.e. 2-hydroxy-3-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus
beta-thujaplicin i.e. 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus
beta-thujaplicinol i.e. 2,7-dihydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus
gamma-thujaplicin i.e. 2-hydroxy-5-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus
manicol i.e. 1,2,3,4-tetrahydro-2,7-dihydroxy-9-methyl-2-(1-methylethyl)-6H-benzocyclohepten-6-one Human Immunodeficiency Virus
additional information selectivity of tropolone derivatives for HIV-1 and HIV-2 enzymes, IC50 values, inhibition mechanism, overview Human Immunodeficiency Virus
nootkatin i.e. 2-hydroxy-5-(3-methyl-2-butenyl)-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus
tropolone i.e. 2-hydroxy-2,4,6-cycloheptatrien-1-one Human Immunodeficiency Virus

Organism

Organism UniProt Comment Textmining
Human Immunodeficiency Virus
-
 i.e. HIV-1 and HIV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O
-
 Human Immunodeficiency Virus ?
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme is part of the viral reverse transcriptase Human Immunodeficiency Virus
ribonuclease H
-
 Human Immunodeficiency Virus
RNase H
-
 Human Immunodeficiency Virus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Human Immunodeficiency Virus