Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for therapeutic antiviral drug development, design, by combinatorial selection, of dsDNA thioaptamers with selected thiophosphate backbone substitutions inhibiting the RNase activity of the reverse transcriptase and the viral replication, overview | Human immunodeficiency virus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | design of diverse dsDNA thioaptamers with selected thiophosphate backbone substitutions effectively inhibiting the RNase activity of the reverse transcriptase and the viral replication, i.e. thioadaptamer R12-2 or XBY-S2, overview | Human immunodeficiency virus 1 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Human immunodeficiency virus 1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Human immunodeficiency virus 1 | the enzyme plays a key role in viral proliferation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
i.e. HIV-1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid + H2O | substrate preparation, overview | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the enzyme plays a key role in viral proliferation | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the enzyme is part of the viral reverse transcriptase | Human immunodeficiency virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme is part of the viral reverse transcriptase | Human immunodeficiency virus 1 |
ribonuclease H | - |
Human immunodeficiency virus 1 |
RNase H | - |
Human immunodeficiency virus 1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Human immunodeficiency virus 1 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Human immunodeficiency virus 1 |