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Literature summary for 3.1.13.2 extracted from

  • Didierjean, J.; Isel, C.; Querre, F.; Mouscadet, J.F.; Aubertin, A.M.; Valnot, J.Y.; Piettre, S.R.; Marquet, R.
    Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones (2005), Antimicrob. Agents Chemother., 49, 4884-4894.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.13.2

Inhibitors

Inhibitors Comment Organism Structure
3,7-dihydroxytropolones
-
 Human immunodeficiency virus 1
additional information no inhibition by O-methylated 3,7-dihydroxytropolones and tropolones, IC50 values, overview Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 1-2 ions are required for RNase H and integrase activities of the reverse transcriptase, 2 different Mg2+ ions are required for polymerase activity and are loacted in the polymerase active site of the reverse transcriptase, 3,7-dihydroxytropolone inhibitors target the Mg2+ ions, overview Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
 i.e. HIV-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-RNA hybrid + H2O
-
 Human immunodeficiency virus 1 ?
-
 ?
additional information the reverse transcriptase possesses different activity domains and shows RNase H, integrase, and DNA polymerase activities Human immunodeficiency virus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
More the enzyme is part of the viral reverse transcriptase, cf. EC 2.7.7.49, RNA-directed DNA-polymerase Human immunodeficiency virus 1
ribonuclease H
-
 Human immunodeficiency virus 1
RNase H
-
 Human immunodeficiency virus 1

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Human immunodeficiency virus 1

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Human immunodeficiency virus 1