Protein Variants | Comment | Organism |
---|---|---|
A360D | mutation decreases the virus titer to about 50% of that of the wild-type virus | Human immunodeficiency virus 1 |
E396A | mutation decreases the virus titer to about 50% of that of the wild-type virus and has significant effect on the extent of enzyme cleavage | Human immunodeficiency virus 1 |
G359S | mutation decreases the virus titer to about 50% of that of the wild-type virus | Human immunodeficiency virus 1 |
H361A | mutation decreases the virus titer to about 25% of that of the wild-type virus and affects the frequency of the generation of linear viral DNAs with aberrant ends | Human immunodeficiency virus 1 |
K390A | mutation decreases the virus titer less than twofold in comparison of wild-type enzyme | Human immunodeficiency virus 1 |
K395A | mutation decreases the virus titer less than twofold in comparison of wild-type enzyme | Human immunodeficiency virus 1 |
T362A | mutation decreases the virus titer less than twofold in comparison of wild-type enzyme | Human immunodeficiency virus 1 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid duplex + H2O | Human immunodeficiency virus 1 | only cleavage of RNA from a RNA-DNA-duplex | oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
HIV-1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA-RNA hybrid duplex + H2O | only cleavage of RNA from a RNA-DNA-duplex | Human immunodeficiency virus 1 | oligonucleotides terminated with 5'-phosphate and 3'-hydroxyl moiety | - |
? |