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Literature summary for 3.1.11.6 extracted from

  • Chase, J.W.; Richardson, C.C.
    Exonuclease VII of Escherichia coli. Mechanism of action (1974), J. Biol. Chem., 249, 4553-4561.
    View publication on PubMed
Search for more literature for 3.1.11.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
single-stranded DNA + H2O Escherichia coli
-
 hydrolyzed single-stranded DNA oligonucleotides ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 xseA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
duplex DNA containing single-stranded termini + H2O
-
 Escherichia coli hydrolyzed single-stranded DNA
-
 ?
single-stranded DNA + H2O
-
 Escherichia coli hydrolyzed single-stranded DNA oligonucleotides ?
single-stranded DNA + H2O no activity on circular DNA Escherichia coli hydrolyzed single-stranded DNA exclusively oligonucleotides ?
single-stranded DNA + H2O no activity on circular DNA Escherichia coli hydrolyzed single-stranded DNA no mononucleotide production observed ?
single-stranded DNA + H2O processive degradation Escherichia coli hydrolyzed single-stranded DNA exclusively oligonucleotides ?
single-stranded DNA + H2O processive degradation Escherichia coli hydrolyzed single-stranded DNA no mononucleotide production observed ?
single-stranded DNA + H2O no activity on DNA-RNA hybrid molecules Escherichia coli hydrolyzed single-stranded DNA exclusively oligonucleotides ?
single-stranded DNA + H2O no activity on DNA-RNA hybrid molecules Escherichia coli hydrolyzed single-stranded DNA no mononucleotide production observed ?
single-stranded DNA + H2O single stranded DNA of at least 10-20 nucleotides are required for maximal activity Escherichia coli hydrolyzed single-stranded DNA exclusively oligonucleotides ?
single-stranded DNA + H2O single stranded DNA of at least 10-20 nucleotides are required for maximal activity Escherichia coli hydrolyzed single-stranded DNA no mononucleotide production observed ?
single-stranded DNA + H2O no activity on RNA Escherichia coli hydrolyzed single-stranded DNA exclusively oligonucleotides ?
single-stranded DNA + H2O no activity on RNA Escherichia coli hydrolyzed single-stranded DNA no mononucleotide production observed ?
thymine dimers + H2O possible role in repair of ultraviolet damage Escherichia coli hydrolyzed single-stranded DNA
-
 ?