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Literature summary for 3.1.11.5 extracted from

  • Jockovich, M.E.; Myers, R.S.
    Nuclease activity is essential for RecBCD recombination in Escherichia coli (2001), Mol. Microbiol., 41, 949-962.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D1067A chi is not a hot-spot for recombination in the mutant, the mutant is sligthtly defective for recombinational repair Escherichia coli
D1080A chi is not a hot-spot for recombination in the mutant, the mutant is sligthtly defective for recombinational repair Escherichia coli
K1082A chi is not a hot-spot for recombination in the mutant, the mutant is sligthtly defective for recombinational repair Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli first: The enzyme is a potent double-stranded DNA exonuclease that destroys linear DNA produced by restriction of foreign DNA. second: The enzyme promotes repair of double-stranded DNA breaks and genetic recombination in the vicinity of chi recombination hotspots. ?
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
K12
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information first: The enzyme is a potent double-stranded DNA exonuclease that destroys linear DNA produced by restriction of foreign DNA. second: The enzyme promotes repair of double-stranded DNA breaks and genetic recombination in the vicinity of chi recombination hotspots. Escherichia coli ?
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?

Synonyms

Synonyms Comment Organism
ExoV
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Escherichia coli