Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.11.2 extracted from

  • Kow, Y.W.; Wallace, S.S.
    Exonuclease III recognizes urea residues in oxidized DNA (1985), Proc. Natl. Acad. Sci. USA, 82, 8354-8358.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.11.2

Inhibitors

Inhibitors Comment Organism Structure
DNA urea-containg DNA is a competitive inhibitor when apurinic DNA is used as substrate, apurinic DNA inhibits when urea-containing DNA is used as substrate Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5
-
 apurinic DNA
-
 Escherichia coli
9.5
-
 Urea-containing DNA
-
 Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ optimal concentration: 2-10 mM Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
double-stranded DNA + H2O Escherichia coli the principal biological role is the repair of DNA damage produced by free radicals ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apurinic DNA + H2O
-
 Escherichia coli ?
-
 ?
double-stranded DNA + H2O apurinic DNA Escherichia coli additional information
-
 ?
double-stranded DNA + H2O the principal biological role is the repair of DNA damage produced by free radicals Escherichia coli ?
-
 ?
additional information endonucleolytic activity against apurinic DNA and against urea residues, nicking on the 5'-side of the damage Escherichia coli ?
-
 ?
urea-containing DNA + H2O
-
 Escherichia coli ?
-
 ?