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Literature summary for 3.1.11.1 extracted from
- Exonuclease 1-dependent and independent mismatch repair (2015), DNA Repair, 32, 24-32 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo | ? | - |
? |  |
| additional information | Homo sapiens | the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo | ? | - |
? | |
| nicked DNA containing mismatches + H2O | Saccharomyces cerevisiae | - |
? | - |
? | |
| nicked DNA containing mismatches + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UQ84 | - |
- |
| Saccharomyces cerevisiae | P39875 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme has 5'-3' double stranded DNA exonuclease and flap endonuclease activities. The enzyme functions to excise the daughter strand after mispair recognition. Additionally, the enzyme functions in end resection during recombination. However, it is not absolutely required for end resection during recombination in vivo | Homo sapiens | ? | - |
? | |
| nicked DNA containing mismatches + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
| nicked DNA containing mismatches + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Exo1 | - |
Saccharomyces cerevisiae |
| Exo1 | - |
Homo sapiens |
| exonuclease 1 | - |
Saccharomyces cerevisiae |
| exonuclease 1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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