Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | in S-phase cells both hEXO1 isoforms accumulate in proliferating cell nuclear antigen-positive foci. After UV irradiation of cells both hEXO1a and hEXO1b accumulated similarly at local UV-induced DNA damages, LUDS, colocalizing with NER preincision factors. Inhibition of repair synthesis enhances hEXO1 accumulation at LUDs | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | endogenous hEXO1 interacts with XPA | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | endogenous hEXO1 interacts with XPA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Exo1 | - |
Homo sapiens |
exonuclease 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | exonuclease 1 is highly conserved from yeast to human | Homo sapiens |
malfunction | in nonreplicating cells, depletion or downregulation of hEXO1 reduces unscheduled DNA synthesis after UV irradiation, prevents ubiquitylation of histone H2A, and impairs activation of the checkpoint signal transduction cascade in response to UV damage | Homo sapiens |
physiological function | exonuclease 1 is implicated in numerous DNA metabolic pathways, including repair, recombination, replication, and telomere maintenance. Key role for hEXO1 in the UV-induced DNA damage response linking NER to checkpoint activation in human cells. hEXO1 accumulation requires XPF-dependent processing of UV-induced lesions and is enhanced by inhibition of DNA repair synthesis | Homo sapiens |