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Literature summary for 3.1.11.1 extracted from

  • Klapacz, J.; Meira, L.B.; Luchetti, D.G.; Calvo, J.A.; Bronson, R.T.; Edelmann, W.; Samson, L.D.
    O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo (2009), Proc. Natl. Acad. Sci. USA, 106, 576-581.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.11.1

Application

Application Comment Organism
molecular biology Exo1 plays an important role in the induction of apoptosis by unrepaired O6-methylguanines Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals ?
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 ?
additional information Mus musculus C57/BL6J Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6J mice
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Mus musculus C57/BL6J
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 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
MEF cell
-
 Mus musculus
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spleen
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals Mus musculus ?
-
 ?
additional information Exo1-null mutant, is impaired in the excision step of mismatch repair. Absence of Exo1 activity diminishes/completely eliminates O6-methylguanines-induced apoptosis. Ablation of Exo1 function renders Mgmt-null cells just as resistant to alkylation-induced cytotoxicity as wild-type cells. Exo1 defect leads to a variable tissue-specific alkylation resistance phenotype. Mgmt-/- Exo1-/- mice show decreased alkylation-induced splenic atrophy, decreased alkylation-induced apoptosis in thymus and spleen tissues and decreased alkylation-induced bone marrow ablation compared with that in Mgmt-/- animals Mus musculus C57/BL6J ?
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 ?

Synonyms

Synonyms Comment Organism
Exo1
-
 Mus musculus
exonuclease 1
-
 Mus musculus