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Literature summary for 3.1.11.1 extracted from

  • Zhu, Z.; Chung, W.H.; Shim, E.Y.; Lee, S.E.; Ira, G.
    Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends (2008), Cell, 134, 981-994.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.11.1

Protein Variants

Protein Variants Comment Organism
additional information initiation of resection in exo1DELTA mutant cells is comparable to that in wild-type cells. In exo1DELTA sgs1DELTA double mutants, the Mre11-Rad50-Xrs2 complex together with Sae2 nuclease generate, in a stepwise manner, only few hundred nucleotides of ssDNA at the break, resulting in inefficient gene conversion and G2/M damage checkpoint arrest. Resection in sgs1DELTA exo1DELTA is limited to the vicinity of double-strand break ends and depends on the Mre11-Rad50-Xrs2 complex and Sae2. G2/M checkpoint arrest in response to a single double-strand break is impaired in sgs1D exo1D cells Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae Exo1 is involved in 5' strand resection. Sgs1 and Exo1 can act independently to remove the 5' strand. Exo1 promotes resection in the absence of Dna2. Dna2 and Exo1 nucleases process 5' strands at a DSB ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-strand DNA + H2O
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 Saccharomyces cerevisiae ?
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 ?
additional information Exo1 is involved in 5' strand resection. Sgs1 and Exo1 can act independently to remove the 5' strand. Exo1 promotes resection in the absence of Dna2. Dna2 and Exo1 nucleases process 5' strands at a DSB Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
Exo1
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 Saccharomyces cerevisiae
exonuclease 1
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 Saccharomyces cerevisiae