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Literature summary for 3.1.11.1 extracted from

  • Nakada, D.; Hirano, Y.; Sugimoto, K.
    Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway (2004), Mol. Cell. Biol., 24, 10016-10025.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
damaged DNA + H2O Saccharomyces cerevisiae requirement of the Mre11 complex and exonuclease 1, playing overlapping roles, for activation of the Mec1 signaling pathway, Mre11 and Exo1 collaborate in producing long single-stranded DNA tails at double-strand breaks of DNA and promote Mec1 association with the double-strand break, Mre11 and Exo1 contribute to the activation of the replication checkpoint pathway, modeling of complex activity ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
damaged DNA + H2O requirement of the Mre11 complex and exonuclease 1, playing overlapping roles, for activation of the Mec1 signaling pathway, Mre11 and Exo1 collaborate in producing long single-stranded DNA tails at double-strand breaks of DNA and promote Mec1 association with the double-strand break, Mre11 and Exo1 contribute to the activation of the replication checkpoint pathway, modeling of complex activity Saccharomyces cerevisiae ?
-
?
damaged DNA + H2O the enzyme possesses 5' to 3' exonuclease activity and acts in the Mre11 complex producing long single-stranded DNA tails at double-strand breaks of DNA Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
Exo1
-
Saccharomyces cerevisiae
exonuclease 1
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Saccharomyces cerevisiae