Any feedback?
Literature summary for 3.1.11.1 extracted from
- Replication factors license exonuclease I in mismatch repair (2004), Mol. Cell, 15, 164-166.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Escherichia coli | 5634 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview | ? | - |
? |  |
| nicked DNA containing mismatches | Homo sapiens | the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC, and Ku70/80 modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
several enzyme forms in the cell | - |
| Homo sapiens | - |
several enzyme forms in the cell | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview | Escherichia coli | ? | - |
? | |
| additional information | the enzyme is DNA single-strand-specific | Escherichia coli | ? | - |
? | |
| nicked DNA containing mismatches | the enzyme is part of the mismatch repair machinery, MMR, the replication factors PCNA and RFC, and Ku70/80 modulate the directionality of the enzyme-mediated excision in DNA mismatch repair, complex components and reaction process, overview | Homo sapiens | ? | - |
? | |
| nicked DNA containing mismatches | the enzyme is DNA single-strand-specific, replication factors PCNA and RFC determine the enzyme reaction direction of 3' to 5' of EXOI, while WRN is modulated by Ku70/80, mechanism | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the enzymes are component of the mismatch repair machinery, composition and function, overview | Escherichia coli |
| More | the enzymes are component of the mismatch repair machinery, composition and function, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ExoI | - |
Escherichia coli |
| ExoI | - |
Homo sapiens |
| exonuclease I | - |
Escherichia coli |
| exonuclease I | - |
Homo sapiens |
| WRN | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
