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Literature summary for 3.1.11.1 extracted from

  • El-Shemerly, M.; Janscak, P.; Hess, D.; Jiricny, J.; Ferrari, S.
    Degradation of human exonuclease 1b upon DNA synthesis inhibition (2005), Cancer Res., 65, 3604-3609.
    View publication on PubMed
Search for more literature for 3.1.11.1

Inhibitors

Inhibitors Comment Organism Structure
additional information hydroxyurea induces degradation of Exo1b via polyubiquitinylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in repair of DNA which is damaged by UV radiation, the constitutive enzyme is phosphorylated and rapidly degraded upon arrest of DNA replication in S phase via the ubiquitin-proteasome pathway, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Exo1b is phosphorylated in response to inhibition of DNA synthesis signaling for the rapid degradation of the enzyme via the ubiquitin-proteasome pathway Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in repair of DNA which is damaged by UV radiation, the constitutive enzyme is phosphorylated and rapidly degraded upon arrest of DNA replication in S phase via the ubiquitin-proteasome pathway, regulation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EXO1b
-
 Homo sapiens
exonuclease 1b
-
 Homo sapiens