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Literature summary for 3.1.1.89 extracted from

  • Kaur, A.; Westermarck, J.
    Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1 (2016), Biochem. Soc. Trans., 44, 1683-1693 .
    View publication on PubMed
Search for more literature for 3.1.1.89

Inhibitors

Inhibitors Comment Organism Structure
ABL127 aza-beta-lactum inhibitor Homo sapiens
ABL127 aza-beta-lactum inhibitor Mus musculus
AMZ30 sulfonyl acrylonitrile inhibitor Homo sapiens
AMZ30 sulfonyl acrylonitrile inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O Homo sapiens the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms [phosphatase 2A protein]-leucine + methanol
-
 ?
[phosphatase 2A protein]-leucine methyl ester + H2O Mus musculus the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms [phosphatase 2A protein]-leucine + methanol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y570
-
-
Mus musculus Q8BVQ5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
embryonic kidney cell line
-
 Homo sapiens
-
glioma cell in human glioma cell, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance Homo sapiens
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[phosphatase 2A protein]-leucine methyl ester + H2O
-
 Homo sapiens [phosphatase 2A protein]-leucine + methanol
-
 ?
[phosphatase 2A protein]-leucine methyl ester + H2O
-
 Mus musculus [phosphatase 2A protein]-leucine + methanol
-
 ?
[phosphatase 2A protein]-leucine methyl ester + H2O the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms Homo sapiens [phosphatase 2A protein]-leucine + methanol
-
 ?
[phosphatase 2A protein]-leucine methyl ester + H2O the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms Mus musculus [phosphatase 2A protein]-leucine + methanol
-
 ?

Synonyms

Synonyms Comment Organism
PME-1
-
 Homo sapiens
PME-1
-
 Mus musculus
PPME1
-
 Mus musculus
protein phosphatase methylesterase-1
-
 Homo sapiens
protein phosphatase methylesterase-1
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 pH and temperature not specified in the publication Homo sapiens ABL127
0.0005
-
 pH and temperature not specified in the publication Homo sapiens AMZ30

General Information

General Information Comment Organism
malfunction PME-1 knockdown by siRNA or shRNA inhibits cancer cell growth not only in in vitro but also in in vivo endometrial cancer xenograft models Homo sapiens
malfunction PME-1 knockdown by siRNA or shRNA inhibits cancer cell growth not only in in vitro but also in in vivo endometrial cancer xenograft models Mus musculus
metabolism the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms. It promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance Homo sapiens
metabolism the enzyme negatively regulates protein phosphatase 2A activity by highly complex mechanisms. It promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance Mus musculus