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Literature summary for 3.1.1.8 extracted from

  • Begum, S.; Nizami, S.S.; Mahmood, U.; Masood, S.; Iftikhar, S.; Saied, S.
    In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as butyrylcholinesterase (BChE) inhibitors (2018), Comput. Biol. Chem., 74, 212-217 .
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
galantamine
-
 Equus caballus
additional information in-vitro evaluation and in-silico studies on amide derivatives of N-phthaloylglycine as butyrylcholinesterase (BChE) inhibitors. The compounds dock into the binding pocket of butyrylcholinesterase enzyme showing interactive amino acid residues of the binding gorge, docking study, overview Equus caballus
N,N-di-sec-butyl-2-(1,3-dioxoisoindolin-2-yl)acetamide
-
 Equus caballus
N,N-dibutyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
-
 Equus caballus
N,N-dicyclohexyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
-
 Equus caballus
N-(cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide
-
 Equus caballus

Organism

Organism UniProt Comment Textmining
Equus caballus P81908
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Equus caballus
-
serum
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Equus caballus
butyrylcholinesterase
-
 Equus caballus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Equus caballus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.5
-
 pH 8.0, 25°C Equus caballus N,N-dibutyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
7.4
-
 pH 8.0, 25°C Equus caballus N,N-di-sec-butyl-2-(1,3-dioxoisoindolin-2-yl)acetamide
17.2
-
 pH 8.0, 25°C Equus caballus N,N-dicyclohexyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
136
-
 pH 8.0, 25°C Equus caballus N-(cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide