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Literature summary for 3.1.1.8 extracted from
- Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and beta-secretase 1 inhibitors (2016), Arch. Pharm. Res., 39, 794-805 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-O-galloyl-D-sedoheptulose | a mixed-type inhibitor, enzyme interacting residues, overview | Homo sapiens |  |
| Berberine | - |
Homo sapiens | |
| loganin | a mixed-type inhibitor, enzyme interacting residues, overview | Homo sapiens | |
| additional information | kinetics and molecular docking studies of loganin, morroniside, and 7-O-galloyl-D-sedoheptulose derived from Cornus officinalis fruits (Corni fructus) as cholinesterase and beta-secretase 1 inhibitors, overview | Homo sapiens | |
| morroniside | a mixed-type inhibitor, enzyme interacting residues, overview | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | Homo sapiens | - |
choline + butyrate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P06276 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | - |
Homo sapiens | choline + butyrate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Homo sapiens |
| butyrylcholinesterase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06935 | - |
loganin | pH and temperature not specified in the publication | Homo sapiens | |
| 0.09506 | - |
morroniside | pH and temperature not specified in the publication | Homo sapiens | |
| 0.13502 | - |
7-O-galloyl-D-sedoheptulose | pH and temperature not specified in the publication | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00685 | - |
pH and temperature not specified in the publication | Homo sapiens | Berberine | |
| 0.03302 | - |
pH and temperature not specified in the publication | Homo sapiens | loganin | |
| 0.03778 | - |
pH and temperature not specified in the publication | Homo sapiens | morroniside | |
| 0.08794 | - |
pH and temperature not specified in the publication | Homo sapiens | 7-O-galloyl-D-sedoheptulose | |
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