Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.8 extracted from

  • Yoon, Y.K.; Ali, M.A.; Wei, A.C.; Choon, T.S.; Khaw, K.Y.; Murugaiyah, V.; Osman, H.; Masand, V.H.
    Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors (2013), Bioorg. Chem., 49, 33-39.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
1-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-4-ethylmorpholin-1-ium
-
 Homo sapiens
3-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
 Homo sapiens
3-[5-(ethoxycarbonyl)-2-(4-hydroxyphenyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
 Homo sapiens
3-[5-(ethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
 Homo sapiens
donepezil
-
 Homo sapiens
ethyl 1-(3-(1H-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate best inhibitor Homo sapiens
rivastigmine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-butyrylthiocholine + H2O
-
 Homo sapiens butyrate + thiocholine
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens
butyrylcholinesterase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00512
-
 at pH 8.0, temperature not specified in the publication Homo sapiens ethyl 1-(3-(1H-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate
0.00659
-
 at pH 8.0, temperature not specified in the publication Homo sapiens 3-[5-(ethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
0.00681
-
 at pH 8.0, temperature not specified in the publication Homo sapiens 3-[5-(ethoxycarbonyl)-2-(4-hydroxyphenyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
0.00795
-
 at pH 8.0, temperature not specified in the publication Homo sapiens donepezil
0.01144
-
 at pH 8.0, temperature not specified in the publication Homo sapiens 3-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
0.01808
-
 at pH 8.0, temperature not specified in the publication Homo sapiens 1-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-4-ethylmorpholin-1-ium
0.022
-
 at pH 8.0, temperature not specified in the publication Homo sapiens rivastigmine