Literature summary for 3.1.1.8 extracted from

Dillon, G.P.; Gaynor, J.M.; Khan, D.; Carolan, C.G.; Ryder, S.A.; Marquez, J.F.; Reidy, S.; Gilmer, J.F.
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability (2010), Bioorg. Med. Chem., 18, 1045-1053.

Search for more literature for 3.1.1.8

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(benzylaminocarbonyloxy)-5-(phenylcarbonyloxyimino-)-1,4 3,6-dianhydro-D-glucitol	9% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-deoxy, 5-dehydro-((ethyloxycarbonyl)ene-)-1,4 3,6-dianhydro-D-glucitol	4.9% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-deoxy-5-phenylcarbonylamino-1,4 3,6-dianhydro-D-glucitol	46% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-deoxy-L-xylohex-6-enitol	9.8% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-keto-1,4 3,6-dianhydro-D-glucitol	10% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-ketoxime-1,4 3,6-dianhydro-D-glucitol	83% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-O-(phenylpropyloxy)-1,4 3,6-dianhydro-D-glucitol	55% inhibition at 0.1 mM	Homo sapiens
2-(benzylaminocarbonyloxy)-5-O-benzyl-1,4 3,6-dianhydro-D-glucitol	55% inhibition at 0.1 mM	Homo sapiens
5-deoxy-5-azido-1,4 3,6-dianhydro-D-glucitol	5% inhibition at 0.1 mM	Homo sapiens
7-exo-(benzylaminocarbonyloxy)-3-oxo-2,5,9-trioxabicyclo [4.3.0] nonane	10% inhibition at 0.1 mM	Homo sapiens
isosorbide-di-(4-nitrophenyl carbamate)	-	Homo sapiens
isosorbide-di-(benzylcarbamate)	77% inhibition at 0.1 mM	Homo sapiens
isosorbide-di-(butylcarbamate)	13% inhibition at 0.1 mM	Homo sapiens
isosorbide-di-(ethylcarbamate)	-	Homo sapiens
isosorbide-di-(propylcarbamate)	28% inhibition at 0.1 mM	Homo sapiens
isosorbide-di-phenylcarbamate	77% inhibition at 0.1 mM	Homo sapiens
N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane	6.5% inhibition at 0.1 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
butyrylthiocholine + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
BChE	-	Homo sapiens
butyrylcholinesterase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0054	-	-	Homo sapiens	isosorbide-di-(4-nitrophenyl carbamate)
0.0065	-	-	Homo sapiens	isosorbide-di-(ethylcarbamate)

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)