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Literature summary for 3.1.1.8 extracted from

  • Belluti, F.; Piazzi, L.; Bisi, A.; Gobbi, S.; Bartolini, M.; Cavalli, A.; Valenti, P.; Rampa, A.
    Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors (2008), Eur. J. Med. Chem., 44, 1341-1348.
    View publication on PubMed
Search for more literature for 3.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
 Homo sapiens
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
 Homo sapiens
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
 Homo sapiens
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
 Homo sapiens
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
 Homo sapiens
donepezil
-
 Homo sapiens
additional information design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyrylthiocholine iodide + H2O detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB Homo sapiens butyrate + thiocholine iodide
-
 ?

Synonyms

Synonyms Comment Organism
BChE
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0074
-
-
 Homo sapiens donepezil
0.0162
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
0.0332
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
0.044
-
 above, pH 8.0, 37°C Homo sapiens (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0607
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0715
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
0.0888
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
0.1
-
 pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
0.1
-
 above, pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
0.1
-
 above, pH 8.0, 37°C Homo sapiens (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
0.125
-
 pH 8.0, 37°C Homo sapiens (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
0.172
-
 pH 8.0, 37°C Homo sapiens (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone