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Literature summary for 3.1.1.8 extracted from

  • Gagnaire, B.; Geffard, O.; Xuereb, B.; Margoum, C.; Garric, J.
    Cholinesterase activities as potential biomarkers: Characterization in two freshwater snails, Potamopyrgus antipodarum (Mollusca, Hydrobiidae, Smith 1889) and Valvata piscinalis (Mollusca, Valvatidae, Mueller 1774) (2008), Chemosphere, 71, 553-560.
    View publication on PubMed

Application

Application Comment Organism
environmental protection the enzyme may be employed as a biological indicator for assessing pesticide contamination Potamopyrgus antipodarum

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 inhibits acetylthiocholinesterase and propionylthiocholinesterase activities, but not butyrylthiocholineesterase activity Potamopyrgus antipodarum
BW284c51 inhibits acetylthiocholinesterase, propionylthiocholinesterase and butyrylthiocholineesterase activities Valvata piscinalis
chlorpyrifos the enzyme activity is significantly decreased by environmental realistic chlorpyrifos concentrations of 2.86 and 14.2 nM after seven days of contact Potamopyrgus antipodarum
eserine
-
Potamopyrgus antipodarum
eserine
-
Valvata piscinalis
iso-ompa inhibits butyrylthiocholineesterase activity Potamopyrgus antipodarum
additional information no inhibition by chlorpyrifos Valvata piscinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
acetylthiocholine pH 7.8 Potamopyrgus antipodarum
0.32
-
propionylthiocholine pH 7.8 Potamopyrgus antipodarum
1.31
-
acetylthiocholine pH 7.8 Valvata piscinalis
3.19
-
propionylthiocholine pH 7.8 Valvata piscinalis

Organism

Organism UniProt Comment Textmining
Potamopyrgus antipodarum
-
a freshwater snail
-
Valvata piscinalis
-
a freshwater snail
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Potamopyrgus antipodarum
additional information
-
-
Valvata piscinalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Potamopyrgus antipodarum thiocholine + acetate
-
?
acetylthiocholine + H2O
-
Valvata piscinalis thiocholine + acetate
-
?
butyrylthiocholine + H2O low activity Potamopyrgus antipodarum thiocholine + butyrate
-
?
butyrylthiocholine + H2O low activity Valvata piscinalis thiocholine + butyrate
-
?
additional information substrate specificity, overview Potamopyrgus antipodarum ?
-
?
additional information substrate specificity, overview Valvata piscinalis ?
-
?
propionylthiocholine + H2O
-
Potamopyrgus antipodarum thiocholine + propionate
-
?
propionylthiocholine + H2O
-
Valvata piscinalis thiocholine + propionate
-
?

Synonyms

Synonyms Comment Organism
ChE
-
Potamopyrgus antipodarum
ChE
-
Valvata piscinalis
cholinesterase
-
Potamopyrgus antipodarum
cholinesterase
-
Valvata piscinalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Potamopyrgus antipodarum
7.8
-
assay at Valvata piscinalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000024
-
pH 7.8, versus butyrylthiocholine Potamopyrgus antipodarum eserine
0.000034
-
pH 7.8, versus acetylthiocholine Potamopyrgus antipodarum eserine
0.00139
-
pH 7.8, versus acetylthiocholine Valvata piscinalis eserine
0.0014
-
pH 7.8, versus butyrylthiocholine Valvata piscinalis eserine
0.00529
-
pH 7.8, versus propionylthiocholine Potamopyrgus antipodarum eserine
0.00868
-
pH 7.8, versus propionylthiocholine Valvata piscinalis eserine
0.15
-
pH 7.8, versus acetylthiocholine Valvata piscinalis BW284c51
0.262
-
pH 7.8, versus propionylthiocholine Valvata piscinalis BW284c51
0.29
-
pH 7.8, versus acetylthiocholine Potamopyrgus antipodarum BW284c51
0.387
-
pH 7.8, versus propionylthiocholine Potamopyrgus antipodarum BW284c51