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Literature summary for 3.1.1.8 extracted from
- Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases (2005), J. Phys. Chem. B, 109, 23070-23076.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P06276 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+/-)-cocaine + H2O | - |
Homo sapiens | ? | - |
? |  |
| acetylcholine + H2O | - |
Homo sapiens | choline + acetate | - |
? | |
| additional information | the oxoanion hole of enzyme can lower the energy barrier for the acetylcholine hydrolysis significantly more than that for cocaine hydrolysis | Homo sapiens | ? | - |
? | |
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