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Literature summary for 3.1.1.79 extracted from

  • Marvyn, P.M.; Bradley, R.M.; Button, E.B.; Mardian, E.B.; Duncan, R.E.
    Fasting upregulates adipose triglyceride lipase and hormone-sensitive lipase levels and phosphorylation in mouse kidney (2015), Biochem. Cell Biol., 93, 262-267 .
    View publication on PubMed
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Application

Application Comment Organism
medicine adipose triglyceride lipase Atgl and hormone-sensitive lipase Hsl mRNA expression is time-dependently increased by fasting, along with other fatty acid metabolism genes (Pparx02, Cd36, and Aox). ATGL and HSL protein levels are induced by 239 and 322%, respectively. There is an increase in ATGL phosphorylation at the AMPK-regulated serine 406 site in the 14-3-3 binding motif, and an increase in HSL phosphorylation at serines 565 and 660 that are regulated by AMPK and PKA, respectively Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein fasting induces an increase in HSL phosphorylation at serines 565 and 660 that is regulated by PKA Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Mus musculus
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General Information

General Information Comment Organism
physiological function adipose triglyceride lipase Atgl and hormone-sensitive lipase Hsl mRNA expression is time-dependently increased by fasting, along with other fatty acid metabolism genes (Pparx02, Cd36, and Aox). ATGL and HSL protein levels are induced by 239 and 322%, respectively. There is an increase in ATGL phosphorylation at the AMPK-regulated serine 406 site in the 14-3-3 binding motif, and an increase in HSL phosphorylation at serines 565 and 660 that are regulated by AMPK and PKA, respectively Mus musculus